Discussion Map
Where to ask, debate, and contribute — substantive discussion is unified; process is split by activity
Quick links: All GitHub Discussions · Substantive hub (#3) · PQ framing hub (#4) · Workshop hub (#2) · Platform & UX hub (#16)
How feedback becomes changes
Two channels, two speeds:
Hypothes.is → quick fix (hours) Navigate to the page where you noticed the problem — the model dashboard, learn page, TEA comparison, or workshop site — then click the < tab on the right edge of that page to open Hypothes.is and annotate the specific text. (Hypothes.is runs on those sites, not on GitHub itself.) No GitHub account needed; free Hypothes.is account takes ~30 seconds. The team monitors all annotations and you’ll see a Claude: confirmation annotation on your thread when the fix is implemented.
GitHub Discussions → model/site commit (days) Post in the Substantive hub (#3) for anything that needs expert debate rather than a quick fix. Resolved discussions are committed to the model or site with the discussion linked in the commit message. Track implementation in the git log.
Not sure which channel? Annotate first. If it needs broader discussion, the team will open a GitHub thread and link your annotation.
The structure
Substantive discussion is unified. Biology, economics, statistics, engineering, and welfare debates happen in one place — the Substantive discussion hub — rather than fragmenting across Workshop / Model / PQ silos.
Process discussion is split by activity — three separate hubs for three distinct coordination tasks: workshop logistics, PQ framing, and platform/UX.
GitHub Discussions is a flat stack of threads per category; the structure below is maintained by hand.
Quick decision tree
| I want to… | Use… |
|---|---|
| Comment on a specific line, paragraph, parameter, or equation | Hypothesis — click the < tab on the right edge of any dashboard page (a free Hypothesis account is required, signup takes ~30 seconds) |
| Debate actual cost values, biology, engineering, welfare, or methodology | Substantive hub (#3) |
| Discuss how to frame a Pivotal Question (resolution, jurisdiction fork, retiring/splitting) | PQ framing hub (#4) |
| Discuss workshop logistics, scheduling, session format | Workshop hub (#2) |
| Suggest UX, visual, page-layout, or commenting-tool improvements | Platform & UX hub (#16) |
| Report a code bug | GitHub Issues |
Reading GitHub Discussions is open to everyone; posting requires a free GitHub account.
Substantive discussion (unified)
Hub: #3 Substantive discussion hub · category: Q&A · all Q&A threads
Unified home for biology, economics, statistics/methodology, engineering, and welfare discussion. Organized by domain.
Currently seeking bio / engineering expert input
- #12 Hydrolysates: how confident are we they’ll replace amino acids in basal media? — 🤝 has expert input from Oana Kubinyecz clarifying hydrolysates vs GF distinction; seeking verification of the 75% baseline adoption estimate
- #17 Is cell density correlated with the cost/L of basal media? — 🤖 Claude analytical take posted (perfusion-density coupling, GF-inclusion ambiguity); awaiting expert verification
Seed topics (reply below or start a new thread)
| Domain | Thread | Scope |
|---|---|---|
| Media, amino acids & nutrients | #9 Pharma-grade media at $0.50–2.50/L? | Media cost range; CM_14 / CM_15 / CM_17 |
| Growth factors & biotech | #13 Growth factors & hydrolysates to 2036 | CM_12 / CM_13 / CM_18 / CM_19 |
| Bioreactors, cell density & scale-up | #14 Bioreactors, cell density & scale-up | CM_16 / CM_17 / CM_20; CAPEX |
| Statistics & methodology | #10 Maturity-factor correlation | Latent factor; WACC / reactor / tech coupling |
| Welfare & impact | #15 Welfare comparison & counterfactuals | CM_02 / CM_10 / CM_11 (substance) |
Start a new substantive thread →
Provenance tags: 🧑 human-drafted · 🤖 AI-generated · 🤝 human-refined from AI / verifying an AI take.
Process / Meta (split by activity)
Three separate hubs for three distinct coordination tasks. Substantive content does not live here — it lives in the Substantive hub above.
Workshop logistics
Hub: #2 Workshop logistics & process hub · category: General · all General threads
Session prep, scheduling, agenda, format, follow-ups for the May 2026 workshop.
Seed topics: (None yet.)
PQ framing & operationalization
Hub: #4 PQ framing hub · category: Ideas · all Ideas threads
How we frame the Pivotal Questions — resolution criteria, jurisdiction forks, retiring/splitting PQs, operationalization of sub-questions CM_12–CM_20.
| PQ | Framing seed | Metaculus |
|---|---|---|
| CM_01 — Focal cost | #5 | link |
| CM_03 — Predict-experts (cost) | #6 | link |
| CM_10 — Predict-experts (welfare) | #7 | link |
| CM_11 — Direct welfare | #8 | link |
Substantive discussion of these PQs (actual estimates, counterfactual reasoning) lives in the Substantive hub (#3), not in the per-PQ framing seeds.
Platform, UX & commenting process
Hub: #16 Platform, UX, page formatting & commenting · category: Ideas
Dashboard UX, visualization design, page organization, documentation clarity, commenting tools (Hypothesis vs Discussions vs giscus), and the structure of this discussion space itself.
Start a new platform / UX / process thread →
External resources
- 📊 Interactive model dashboard
- 📖 Technical docs
- 🔬 Learn: how cultured chicken is made
- 🆚 TEA comparison
- 🧑🏫 Workshop site
- 🎯 Pivotal Questions landing
- 📘 PQ background (GitBook)
- 💻 GitHub repo
This map is maintained by hand. If a thread is missing or the map feels stale, ping us via any of the channels above and we’ll update it.